Free radicals and antioxidants in two oxidative-stress cell models exposed to ochratoxin A and amyloid β: unexpected results
2010
Costa, S. | Cervellati, R. | Speroni, E. | Guerra, M. | Greco, E.
Oxidative stress is reported to be closely related to pathogenetic mechanisms and plays a central role in several molecular toxicities. It seems reasonable to hypothesize that antioxidant molecules and/or free radical scavengers can protect from oxidative stress-induced damage by quenching free-radical reactions. Leontopodic acid (LA) is a fully substituted, hexaric acid derivative isolated from Leontopodium alpinum Cass., commonly known as ‘Edelweiss’ (Asteraceae family), and exhibits significant chemical antioxidant power. The present study was designed to evaluate LA’s capacity to counteract induced oxidative stress in two in vitro cell models: one exposed the LLC-PK1 cell line to ochratoxin A and the other exposed the differentiated SH-SY5Y cells to amyloid β. The effects of a 24 h pretreatment with LA on induced ROS (reactive oxygen species) production and cytotoxicity were evaluated in the two models. Surprisingly, the results showed that while LA decreased ROS production, it did not increase cell survival.
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