Effect on lipoprotein profile of replacing butter with margarine in a low fat diet: randomised crossover study with hypercholesterolaemic subjects
1996
Objective- To examine the effect on lipid and lipoprotein concentrations when butter or an unsaturated margarine is used for cooking or spreading in a reduced fat diet. Design-Randomised crossover study with two intervention periods of six weeks' duration separated by a five week washout. Setting-Community setting in New Zealand. Subjects-49 volunteers with polygenic hypercholesterolaemia and baseline total cholesterol concentration in the range 5.5-7 9 mmol/l. Main outcome measures-Concentrations of total and low density lipoprotein, Lp(a) lipoprotein, high density lipoprotein, apolipoprotein B 100, and apolipoprotein A I. Results-Concentrations of low density lipoprotein cholesterol and apolipoprotein B were about 10%. Lower with margarine than with butter. Lp(a) lipoprotein and high density lipoprotein cholesterol concentrations were similar with the two diets. Conclusion-Despite concerns about adverse effects on lipoproteins of trans fatty acids in margarines, the use of unsaturated margarine rather than butter by hypercholesterolaemic people is associated with a lipoprotein profile that would be expected to reduce cardiovascular risk.
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