Effect of ascorbic acid on lipid profile and lipid peroxidation in hypercholesterolemic rabbits
1997
Das, S. | Snehlata. | Srivastava, L.M.
Four groups of rabbits were studied for 6, 10, and 16 weeks to determine the effect of ascorbic acid on cholesterol induced hypercholesterolemia. Serum concentrations of triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C) and malondialdehyde (MDA) were studied. TC, LDL-C and VLDL-C increased significantly in cholesterol fed rabbits whereas in cholesterol and ascorbic acid fed rabbits, the increase was significant but less than the previous group, in comparison to controls. The MDA level increased by 16% after 16 weeks in cholesterol fed groups whereas in cholesterol and ascorbic acid fed groups the MDA level was normal. The results indicate that ascorbic acid administration reduces the development of hypercholesterolemia in rabbits through its antioxidant property.
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