Synthesis and antitumor activity of benzophenone compound
2022
Zhou, Bei-Dou | Wei, Rong-Rong | Li, Jia-Li | Yu, Zi-Han | Weng, Zhi-Min | Ruan, Zhi-Peng | Lin, Jian | Fang, Yuan-Yuan | Xu, Gui-Fen | Hu, Dong-Bao
Seven benzophenone compounds were synthesized in one or two steps, then their antitumor activity was evaluated. The total yields ranged from 9% to 44%. Compounds 3c–5c exhibited obvious antitumor activity. Among them, compounds 3c and 4c exhibited excellent and broad-spectrum antitumor activity. Compound 3c exhibited much stronger inhibitory activities against fourteen cancer cells than cisplatin. In particular, compound 3c exhibited stronger cytotoxicity against hepatocarcinoma SMMC-7721 cells than Taxol, with a half maximal inhibitory concentration (IC₅₀) of approximately 0.111 μM. These results demonstrated that compounds 3c, 4c and 5c were very promising antitumor leads for further structural modification.
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