Tissue distribution of marbofloxacin after 'systemic' administration into the isolated perfused bovine udder
2008
Kietzmann, Manfred | Michael, Braun | Marc, Schneider | Pankow, Rüdiger
Mammary glands taken at slaughter from healthy lactating cows were perfused in vitro with warmed and gassed Tyrode solution. Marbofloxacin was administered “systemically” via the perfusion fluid at concentrations similar to those measured in plasma following intravenous administration of 2 mg/kg marbofloxacin. Samples from the perfusate were taken over a 24 h period. Glandular tissue samples at different vertical distances from the teat up to the udder base were gathered from each of the four quarters after 3, 6, 12 and 24 h. The marbofloxacin content of the tissue samples was analysed by high performance liquid chromatography with UV detection.
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