Effects of caffeine on plasma renin activity, catecholamines and blood pressure
1978
Robertson, David | Frölich, J. C. (Jurgen C.) | Carr, R.Keith | Watson, J.Throck | Hollifield, John W. | Shand, David G. | Oates, John A.
Extract: Using a double blind, randomized, cross over protocol, the effect of a single dose of oral caffeine on plasma renin activity, catecholamines and cardiovascular control in nine healthy, young, non coffee drinkers maintained in sodium balance was studied. Caffeine increased plasma renin activity 57 percent, plasma norepinephrine by 207 percent. Urinary normetanephrine and metanephrine were increased 52 percent and 100 percent respectively. Mean blood pressure rose 14/10 mm Hg one hour after caffeine ingestion. There was a slight fall and then a rise in heart rate. Under the conditions of study caffeine was a potent stimulator of plasma renin activity and adrenomedullary secretion.
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