One-pot total chemical synthesis of human α-synuclein
2013
FauvetThese authors contributed equally to this work., Bruno | Butterfield, Sara M. | Fuks, Jonas | Brik, Ashraf | Lashuel, Hilal A.
Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.
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