Palladium-catalyzed intramolecular CH acylation of indoles with thioester
2019
Liu, Min | Liu, Yuwen | Xu, Hui | Dai, Hui-Xiong
A palladium-catalyzed intramolecular CH acylation of indole with thioester is described, providing a direct and effective approach for the synthesis of the biologically active indole-indolone scaffolds. The method obviates the need for the prefunctionalized starting materials including organometallic reagents, alkyl halides, and NHP esters in previous metal-catalyzed cross-coupling reaction with thioester. Substrates bearing sensitive halo groups are compatible in the reaction, leaving a functional handle for further structural elaborations.
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