Synthesis of fluorinated building blocks based on spiro[3.3]heptane scaffold
2016
Chernykh, Anton V. | Feskov, Illia O. | Chernykh, Alla V. | Daniliuc, Constantin G. | Tolmachova, Nataliya A. | Volochnyuk, Dmitriy M. | Radchenko, Dmytro S.
New non-flattened amino group-containing building blocks and fluorinated analogs based on the spiro[3.3]heptane motif were synthesized. The syntheses included a challenging deoxofluorination of sterically hindered carbonyl groups via an intermediate carbocation. The synthesized compounds could be useful in medicinal chemistry due to their three-dimensional shape, and a different pattern of the fluorine substitution.
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