Morphofunctional condition of the pancreatic insular apparatus in old rats with alloxan-induced diabetes and its correction with lipoic acid
2020
Yulia, Klyueva | Irina, Danilova | Viktor, Emelianov | Irina, Gette | Ekaterina, Trofimova
The concentration of glucose and glycosylated hemoglobin in the blood of animals increases as a result of physiological aging. This is due to damage to the pancreatic insular apparatus and a decrease in the number and functioning of active β-cells. The development of alloxan-induced diabetes in old rats is characterized by a decrease in the number of islets of Langerhans, an enlargement of the preserved islets, and a sharp decrease in the number of active endocrine cells. The injection of lipoic acid partially corrected the morphofunctional condition of the islets of Langerhans and the biochemical values of the animals’ peripheral blood.
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