Bioactive cassane diterpenoids from the seeds of Caesalpinia sappan
2017
Zhu, Nai-Liang | Xu, Xu-Dong | Hu, Mei-Geng | Sun, Zhong-Hao | Wu, Tong-Yu | Yuan, Jing-Quan | Wu, Haifeng | Tian, Yu | Li, Peng-Fei | Yang, Jun-Shan | Ma, Guo-Xu
Three new cassane-type diterpenoids named caesalppans G-I (1–3) together with three known ones (4–6), were isolated from the methanol extract of Caesalpinia sappan seeds. Their structures were determined based on spectroscopic data. Among the isolated compounds, compound 2 displayed a moderate antimalarial activity with an IC50 value of 2.4μM, and compound 4 showed mild anti-inflammatory activity with an IC50 value of 28.65μM.
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