Perinatal exposure to low-dose decabromodiphenyl ethane increased the risk of obesity in male mice offspring
2018
Yan, Sen | Wang, Dezhen | Teng, Miaomiao | Meng, Zhiyuan | Yan, Jin | Li, Ruisheng | Jia, Ming | Yao, Chenyang | Sheng, Jing | Tian, Sinuo | Zhang, Renke | Zhou, Zhiqiang | Zhu, Wentao
Decabromodiphenyl Ethane (DBDPE), a kind of new brominated flame retardants (NBFRs) used to replace DecaBDE, has been frequently detected in the environment and human samples. In this study, we explored its toxic effects on male mouse offspring after perinatal exposure to DBDPE. During the perinatal period, pregnant ICR mice were exposed to DBDPE (100 μg/kg body weight) via oral gavage. After weaning, male offspring were fed on a low-fat diet and a high-fat diet, respectively. We measured and recorded body weight, liver weight, and epididymis fat mass, blood biochemical markers, metabolites changes in liver, and gene expression involved in lipid and glucose homeostasis. The results showed that perinatal exposure to DBDPE increased the risk of obesity in mouse offspring and affected triglyceride synthesis, bile secretion, purine synthesis, mitochondrial function and glucose metabolism, furthermore, the use of HFD feeding may further exacerbate these effects. All of these results show that early-life exposure to low doses of DBDPE can promote the development of metabolic dysfunction, which in turn induces obesity.
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