Microbial hydroxylation of natural drimenic lactones
1999
Maurs, M. | Azerad, R. | Cortes, M. | Aranda, G. | Delahaye, M.B. | Ricard, L.
Incubation of confertifolin and isodrimenin with Mucor plumbeus, Aspergillus niger or Rhizopus arrhizus gave in good yields the corresponding 3beta-hydroxy derivatives. From isodrimenin, the known natural 7alpha-hydroxy derivative (futronolide) was also obtained and its structure was definitely established by X-ray crystallographic study of its acetate derivative.
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