Zanthoxylum myriacanthum var. pubescens Essential Oil Protective Potential Against Diabetic Mice Nephropathy and its Relevant Oxidative Stress
2019
Dahab, Mahmoud | Fu, Baiting | Osman, Elbadri | Xu, You-Kai | Zhang, Ping
Maqian (Zanthoxylum myriacanthum var. pubescens Huang) is an indigenous aromatic plant in Xishuangbanna of Yunnan in southwest China. The fruits are used by local people not only as a spice for roasting meat and boiling fish but also as a remedy for digestive disorders. The current study evaluated the renoprotective effect of Maqian essential oil (MQEO) in streptozotocin (STZ) induced diabetes in mice. In this study, diabetes in ICR mice was induced by a single dose of STZ (200 mg kg⁻¹ body weight i.p.) injection. Consequently after seven days of administration MQEO to mice, the levels of urea and creatinine oxidative stress parameters and cytokines of TNF-α and IL-1β in kidney were evaluated. Moreover protein expressions of TXNIP, IKKβ, and Nrf2 were examined. Oral administration of MQEO significantly decreased the urine urea and creatinine levels. MQEO treatment also normalized several oxidative stress parameters including malondialdehyde, vitamin C and enzymatic antioxidants in kidney. In addition, TNF-α and IL-1β levels were also significantly reduced by MQEO. Furthermore, MQEO normalized STZ-induced changes in kidney the protein expressions of TXNIP, IKKβ and Nrf2 in the diabetic group. In conclusion, these findings demonstrated that MQEO exerts the potent renoprotective effect by alleviating the kidney oxidative stress.
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