The exposure of OPFRs in fish from aquaculture area: Backward tracing of the ecological risk regulation

In this study, we backward traced and controlled the pollution of organophosphorus flame retardants (OPFRs) in aquaculture areas from the standpoints of terminal treatment, migration and transformation resistance, and source molecular substitution technology. A regulatory plan to considerably reduce the combined biotoxicity of fish exposed to OPFRs in aquaculture areas and significantly improves the biodegradation of sewage treatment and the efficiency of soil plant-microorganism combined remediation was formulated. Environmentally friendly alternatives of OPFRs were designed. The supplementation scheme of aquatic feed significantly alleviates the toxicity risk of fish exposure to OPFRs in aquafarm (reduced by 121.02%). The regulatory scheme of external stimulus to enhance the biodegradation of OPFRs in wastewater treatment process included an H₂O₂ concentration of 400 mg/L, voltage gradient of 1.5 V/m, and pH of 6.5 can improve the degradation capacity of OPFRs molecules by 88.86%. The degradation of OPFRs can be enhanced by plant-microorganism combined remediation (up to 98.64%) by growing plants whose primary function is phytoextraction in soils dominated by Sphingopyxis sp. and Rhodococcus sp. A 3D-QSAR pharmacophore model based on apoptosis toxicity, mitochondrial dysfunction, oxidative stress response, reproductive, neurotoxicity, gill-inhalation combined toxicity of fish exposed to OPFRs in aquafarm was fabricated. The recommended aquatic feed scheme and the control scheme of enhanced degradation of OPFRs by sewage treatment and soil environment had better applicability for the new-designed OPFRs substitution molecules (the maximum combined toxicity/degradation is reduced/increased by 75.46% and 63.24%, respectively). In this paper, a technical scheme of OPFRs terminal treatment, process regulation, and source control was applied as a cradle-to-grave approach to reduce the ecological toxicity risk of fish exposed to OPFRs in aquaculture areas providing theoretical support for the realization of OPFRs environmental pollution control.