Erratum to: Enhanced functional and structural domain assignments using remote similarity detection procedures for proteins encoded in the genome of Mycobacterium tuberculosis H37Rv
2004
Namboori, Seema | Mhatre, Natasha | Sujatha, Sentivel | Srinivasan, Narayanaswamy | Pandit, Shashi Bhushan
The three-dimensional structure and subcellular localization of various domains and sub-domains of Rv1318c, a putative cyclase from Mycobacterium tubercolosis, are currently unknown from experimental studies. We have predicted that Rv1318c consists of five transmembrane helices (Namboori et al 2004). However, depending upon the algorithm for prediction and the parameters used, the predicted number of helices can vary. We have also suggested that the C-terminal cyclase domain of Rv1318c is located intracellularly; this is a conserved feature in the family of adenylyl/guanylyl cyclases. Recently it has been shown experimentally that Rv1318c is an adenylyl cyclase (Linder et al 2004; Eur. J. Biochem. 271 2446–2451).
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