Total Synthesis of Indolizidine Alkaloids via Nickel-Catalyzed (4 + 2) Cyclization
2020
Renner, Jonas | Thakur, Ashish | Rutz, Philipp M. | Cowley, Jacob M. | Evangelista, Judah L. | Puneet Kumar, | Prater, Matthew B. | Stolley, Ryan M. | Louie, Janis
A Ni-catalyzed (4 + 2) cycloaddition of alkynes and azetidinones toward piperidinones was used as key reaction in the enantioselective synthesis of naturally occurring indolizidine alkaloids. The reaction benefits from the use of an easily accessible azetidinone as an advanced and divergent intermediate to build the indolizidine core. This methodology has been applied in the total syntheses of (+)-septicine, (+)-ipalbidine, and (+)-seco-antofine to illustrate the applicability of the general approach.
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