Inhibited Apoptosis of C₂C₁₂ Myoblasts by a Eupatorium chinense var. simplicifolium Root Extract
2013
LEE, Jin-Ho | JUNG, Min-Ho | LEE, Yong-Hyeon | SHIN, Yusu | KIM, Han-Sung | Schreiber, Jürgen | KIM, Tack-Joong
We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C₂C₁₂ myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H₂O₂ treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUC-pre-treated C₂C₁₂ myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.
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