Two New Anti-Tobacco Mosaic Virus Alkaloids from the Whole Plants of Thalictrum microgynum
2022
Wu, Yu-Ping | Lin, Zhong-Long | Zhao, Gao-Kun | Zhou, Min | Yao, Heng | Zhang, Guang-Hai | Li, Wei | Yang, Guang-Yu | Li, Yin-Ke | Hu, Qiu-Fen | Kong, Guang-Hui
Two new (1 and 2), together with four known (3–6) alkaloids were isolated from the whole plants of Thalictrum microgynum. Compounds 1–6 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results indicated that compounds 2–4 showed high anti-TMV activity with inhibition rates of 34.8, 42.1, and 35.2% at a concentration of 20 μM, respectively. These rates were higher than that of ningnanmycin, a positive control. Compounds 1, 5, and 6 also showed potential anti-TMV activity with inhibition rates of 26.7, 24.8, and 28.2%.
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