Synthesis and biological evaluation of 1,3,4,5-tetrasubstituted pyrazole derivatives
2016
Yahyavi, Hoda | Hosseinzadeh, Fatemeh | Karimi, Nastaran | Moghimi, Setareh | Mahdavi, Mohammad | Nadri, Hamid | Moradi, Alireza | Shafiee, Abbas | Foroumadi, Alireza
We report a solvent-free synthesis of novel 1,3,4,5-tetrasubstituted pyrazoles and investigate their inhibitory activity against soybean 15-lipoxygenase. It was revealed that all synthesized compounds exhibited good activity, and among them, 3-(furan-2-yl)-1,4,5-triphenyl-1H-pyrazole (5j) showed 10 times stronger inhibitory activity in comparison to the reference drug quercetin.
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