Transmammary exposure of mouse pups to allium sativum (garlic) and its effect on the neonatal hepatic xenobiotic metabolizing enzymes of mice
1994
Chhabra, S.K. | Rao, A.R.
The present study examines the transmammary modulation of hepatic xenobiotic metabolizing enzymes in the F1 generation mouse pups postnatally exposed to garlic. Lactating Swiss albino mice received either 200 or 400 mg of garlic/kg bw by oral gavage for 14 or 21 days postpartum. The acid soluble sulfhydryl content significantly increased in liver of dams (P < 0.05) on the higher dose of garlic. It however decreased in liver of 14 day old pups (P < 0.01) translactationally exposed to the lower garlic dose. Cytochrome b5 content was not affected with garlic treatment in dams and most of the pups but increased in the 14 day old female pup translactationally exposed to the higher dose of garlic (P < 0.001). Hepatic cytochrome P-450 content and glutathione S-transferase activity remained unchanged in dams and pups exposed to garlic. Glutathione reductase decreased significantly in liver of dams which received the lower garlic dose for 14 or 21 days (P < 0.05) and in the 21 day old pups (P < 0.001). Glutathione peroxidase activity decreased in dams and pups which were exposed to 400 mg garlic/kg bw for 21 days (P < 0.001).
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