Effect of supplements of dikanut (Irvingia gabonensis) and cellulose on plasma lipids and composition of hepatic phospholipids in streptozotocin-induced diabetic rat
1994
Omoruyi, F. | Adamson, I.
Streptozotocin-induced diabetic rats were maintained for 4 weeks on a basic corn-soy diet supplemented with either dikanut (an African viscous dietary fiber) or cellulose (an insoluble fiber). Plasma and liver lipids were determined. The two types of diet significantly reduced glucose, total cholesterol, triglyceride, HDL-cholesterol and LDL + VLDL cholesterol levels in the plasma. The effect of dikanut supplementation was more pronounced. Distribution of phospholipids in the liver [phosphatidyl ethanolamine (PE), phosphatidyl serine (PS), phosphatidyl choline (PC) and phosphatidyl inositol (PI)] were significantly reduced by feeding dikanut and cellulose. Dikanut supplementation caused a significant increase in the level of sphingomyelin (SP) in the liver. The results show that fibers can affect liver phospholipid distributions and may in the process alter the transport of lipids and other nutrients in and out of the liver of the diabetic rat.
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