Oxidative stress mediated cytotoxicity of tin (IV) oxide (SnO2) nanoparticles in human breast cancer (MCF-7) cells
2018
Ahamed, Maqusood | Akhtar, Mohd Javed | Majeed Khan, M.A. | Alhadlaq, Hisham A.
Due to unique optical and electronic properties tin oxide nanoparticles (SnO₂ NPs) have shown potential for various applications including solar cell, catalyst, and biomedicine. However, there is limited information concerning the interaction of SnO₂ NPs with human cells. In this study, we explored the potential mechanisms of cytotoxicity of SnO₂ NPs in human breast cancer (MCF-7) cells. Results demonstrated that SnO₂ NPs induce cell viability reduction, lactate dehydrogenase leakage, rounded cell morphology, cell cycle arrest and low mitochondrial membrane potential in dose- and time-dependent manner. SnO₂ NPs were also found to provoke oxidative stress evident by generation of reactive oxygen species (ROS), hydrogen peroxide (H₂O₂) and lipid peroxidation, while depletion of glutathione (GSH) level and lower activity of several antioxidant enzymes. Remarkably, we observed that ROS generation, GSH depletion, and cytotoxicity induced by SnO₂ NPs were effectively abrogated by antioxidant N-acetylcycteine. Our data have shown that SnO₂ NPs induce toxicity in MCF-7 cells via oxidative stress. This study warrants further research to explore the genotoxicity of SnO₂ NPs in different types of cancer cells.
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