Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells
2020
Zhang, Ya-Li | Zhang, Xiao | Miao, Xiang-Zhen | Yuan, Yan-Yan | Gao, Jian | Li, Xia | Liu, Yong-Gang | Tan, Peng
The effects of coptisine against advanced stage of human pancreatic carcinoma PANC-1 cells was investigated in vitro. Coptisine (25–150 μM) treatment for 48 h caused dose-dependent cell growth inhibition by using CCK-8 assay. Additionally, coptisine was found to inhibit PANC-1 cells metastasis by the wound healing assay. Flow cytometry data indicated that coptisine (25–100 μM) exhibited dose-dependent G1 phase arrest and moderate reduction of S phase. Coptisine was also found to inhibit ERK phosphorylation and total ERK levels. Our research suggested that coptisine would be a potential therapeutic drug for the treatment of pancreatic cancer.
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