Pregnane glycosides from the bark of Marsdenia cundurango and their cytotoxic activity
2019
Tatsuno, Satoru | Yokosuka, Akihito | Hatsuma, Fusako | Mashiko, Yuto | Mimaki, Yoshihiro
Seven new pregnane glycosides (1–7) and eight known compounds (8–15) were isolated from the bark of Marsdenia cundurango (Asclepiadaceae). The structures of 1–7 were determined by spectroscopic analysis, including two-dimension NMR spectroscopy, chemical transformations, and chromatographic analysis of the hydrolyzed products. The isolated compounds 1–15 were evaluated for their cytotoxic activity against HL-60 human leukemia cells, A549 human lung adenocarcinoma cells, and TIG-3 normal human lung cells, including apoptosis-inducing activity of a representative pregnane glycoside in HL-60 cells.
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