One new α-pyrone and one new fatty acid derivative from mangrove-derived fungus Phomopsis sp. HYP11
2022
Cai, Jin | Liu, Jing | Chen, Min-Jing | Wang, Bin | Luo, Yun-Zhan | Zhang, Zi-Yi | Zhang, Xue-Long | Chen, Guang-Ying | Huang, Guo-Lei | Zheng, Cai-Juan
One new α-pyrone derivative (S)-3-(4-methoxy-3-methyl-2-oxo-2H-pyran-6-yl)butyl acetate (1) and one new fatty acid derivative (4S,5S)-5-acetoxy-4-hydroxyhexanoic acid (2), along with six known compounds (3–8) were obtained from the mangrove-derived fungus Phomopsis sp. HYP11. Their structures and absolute configurations were determined by detailed 1D and ²D NMR, HR-ESI-MS spectral, and quantum chemical electronic circular dichroism (ECD) calculations. Compounds 2, 3, 5, 6 and 8 showed antioxidant activity with the IC₅₀ values range of 0.09–0.67 mM, especially compounds 5 and 6 showed stronger antioxidant activity than the positive control trolox (IC₅₀ =0.29 mM). Compound 8 showed weak antagonistic effect on Ralstonia solanacearum with the MIC value of 50 μg/mL.
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