The Bioavailability for humans of bound niacin from wheat bran
1982
Carter, Eric G.A. | Carpenter, Kenneth J.
Extract: Ethanolic wheat bran extracts were dialyzed and dried on starch. One portion (bound niacin (BN)) was cooked in steam; another (alkali-treated bound niacin (ABN)) was made alkaline with calcium oxide, and then cooked. The niacin in BN was bound to large molecules (gel filtration); in ABN it was free. Three subjects each consumed a standard daily diet containing approximately 20 mg niacin equivalents. Urine was collected throughout. From day 14, each received 3 doses in random order at 8-day intervals. The doses (each spread over 2 days) were of BN and ABN, containing 35 mg niacin and 24 mg pure nicotinic acid. The above-base-line response in urinary metabolites (N-methylnicotinamide and N--methyl-2-pyridone-5-carboxamide) over the 6 days from the beginning of each dose was equivalent to 24% of ingested niacin after BN, 62% after ABN, and 89% after nicotinic acid. The niacin in BN appeared mostly unavailable. (author)
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