Chronic treatment with cinnamaldehyde prevents spontaneous atherosclerotic plaque development in ovariectomized LDLr-/- female mice
2020
Moraes, Flávia de Souza Andrade | Dubois Filho, Dionisio Gonzaga | Caliari, Ávila Iglesias | Brasil, Girlandia Alexandre | do Nascimento, Andrews Marques | Kalil, Ieda Carneiro | Scherer, Rodrigo | Endringer, Denise Coutinho | Lenz, Dominik | de Lima, Ewelyne Miranda | de Andrade, Tadeu Uggere
Ischemic cardiovascular diseases, which occur due to atherosclerosis, are among the leading causes of death worldwide. The increase in the occurrence of these diseases among women occurs mainly in the post-menopausal period, due to the decrease in the levels of female hormones. The present study investigated the effects of cinnamaldehyde on atherosclerotic lesions, lipid profiles and oxidative stress in LDLr-/- ovariectomized mice.The lipid deposition in the aortas was determined by the en face method and staining with red oil. Lipid profiles and levels of oxidized LDL were analyzed in blood samples and oxidative stress markers were analyzed in samples of aorta, heart and liver tissue.Cinnamaldehyde prevented lipid deposition in the aorta of female ovariectomized mice. In addition, it was able to improve oxidative stress markers and reduce levels of oxidized LDL.Cinnamaldehyde prevented the development of atherosclerotic lesions in the aorta of LDLr-/- ovariectomized mice and this effect can be justified, at least in part, by its antioxidant activity.
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