Effects of body weight reduction on cardio-ankle vascular index (CAVI)
2013
Nagayama, Daiji | Endo, Kei | Ohira, Masahiro | Yamaguchi, Takashi | Ban, Noriko | Kawana, Hidetoshi | Nagumo, Ayako | Saiki, Atsuhito | Oyama, Tomokazu | Miyashita, Yoh | Shirai, Kohji
OBJECTIVE: Obesity is associated with type 2 diabetes, dyslipidemia and hypertension, contributing to atherogenesis. Weight reduction is the fundamental therapy for obesity. Recently, a novel arterial stiffness parameter called cardio-ankle vascular index (CAVI) has been developed. We hypothesized that CAVI may be a candidate marker of increased vascular stiffness in obese patients. The aim of this study is to investigate the effect of weight reduction on CAVI. SUBJECTS AND METHODS: Using CAVI as an indicator, we assessed the changes in arterial stiffness in 47 obese Japanese subjects (aged 46±13 years) who underwent a 12-week weight reduction program consisting of a calorie restriction diet (20–25kcal/day) and exercise therapy. Visceral fat area (VFA) was evaluated by CT. RESULTS: At baseline, CAVI correlated positively with age (r=0.70), blood pressure (r=0.23), VFA (r=0.26) and HbA1c (r=0.39). After 12 weeks of weight reduction, mean BMI decreased from 33.3±7.5 to 30.7±6.4kg/m² (p<0.0001), and mean CAVI decreased from 8.3 to 7.9 (p<0.01). The change in VFA correlated positively with change in CAVI in subjects with decrease in CAVI (r=0.47). Furthermore, change in VFA was a significant independent predictor for change in CAVI. No significant correlation was observed between change in CAVI and clinical variables such as BMI, HbA1c and lipids. CONCLUSION: This study demonstrated that CAVI decreased after weight reduction, and was associated with a decrease in VFA. CAVI reduction maybe a marker of improved vascular stiffness after weight reduction in subjects with visceral adiposity.
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