Scalable synthesis of secondary and tertiary amines by heterogeneous Pt-Sn/γ-Al2O3 catalyzed N-alkylation of amines with alcohols
2016
Wu, Kaikai | He, Wei | Sun, Chenglin | Yu, Zhengkun
Synthesis of secondary and tertiary amines has been efficiently realized from the N-alkylation of amines with alcohols by means of heterogeneous bimetallic Pt-Sn/γ-Al2O3 catalyst (0.5 wt % Pt, molar ratio Pt:Sn = 1:3) through a borrowing hydrogen strategy. The Pt-Sn/γ-Al2O3 catalyst has exhibited very high catalytic activity towards a wide range of amines and alcohols, and can be conveniently recycled without Pt metal leaching. The present protocol was applied for the synthesis of N-phenylbenzylamine in 96% isolated yield from aniline and benzyl alcohol on a 2.1 kilogram scale of the substrates, demonstrating its potential applicability for higher-order amine synthesis.
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