PconsFam: An Interactive Database of Structure Predictions of Pfam Families
2019
Lamb, John | Jarmolinska, Aleksandra I. | Michel, Mirco | Menéndez-Hurtado, David | Sulkowska, Joanna I. | Elofsson, Arne
At present, about half of the protein domain families lack a structural representative. However, in the last decade, predicting contact maps and using these to model the tertiary structure for these protein families have become an alternative approach to gain structural insight. At present, reliable models for several hundreds of protein families have been created using this approach. To increase the use of this approach, we present PconsFam, which is an intuitive and interactive database for predicted contact maps and tertiary structure models of the entire Pfam database. By modeling all possible families, both with and without a representative structure, using the PconsFold2 pipeline, and running quality assessment estimator on the models, we predict an estimation for how confident the contact maps and structures are for each family.
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