Inhibitory effects of noscapine on dopamine biosynthesis in PC12 cells
1997
Shin, Jung Soo | Lee, Sang Sun | Lee, Myung Koo
The effects of noscapine, a phthalide isoquinoline alkaloid, on dopamine biosynthesis and tyrosine hydroxylase (TH) activity in PC12 cells were investigated. Noscapine showed 74.6% inhibition on dopamine content in PC12 cells at a concentration of 20 μM. IC₅₀ of noscapine was 6.8 μM. TH activity was inhibited by the treatment of noscapine in PC12 cells (20.9% inhibition at 20 μM). Therefore, the inhibition of TH activity by noscapine might be involved in at least one component of the reduction of dopamine biosynthesis in PC12 cells.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por National Agricultural Library