Formylated polyamines as peptidomimetics
2012
Javor, Sacha | Janowsky, Aaron | Johnson, Robert | Wolfrum, Katherine | Tadayoni-Rebek, Mitra | Rebek, Julius, Jr
A new construct for imitating a natural peptide ligand using a modified retro-inverso sequence is described. It is demonstrated through the synthesis of a peptidomimetic derived from the endogenous sequence of leucine enkephalin. The product was active at 400nM and selective for μ-opioid receptors.
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