Biological properties of Alsidium corallinum and its potential protective effects against damage caused by potassium bromate in the mouse liver
2016
Ben Saad, Hajer | Kharrat, Nadia | Krayem, Najeh | Boudawara, Ons | Boudawara, Tahia | Zeghal, Najiba | Ben Amara, Ibtissem
In the course of searching for hepatoprotective agents from natural sources, the protective effect of chemical constituents of the marine red alga Alsidium corallinum (A. corallinum) against potassium bromate (KBrO₃)-induced liver damage in adult mice was investigated. The in vitro antioxidant and antibacterial properties of A. corallinum were firstly investigated. Then, A. corallinum was tested in vivo for its potential protective effects against damage caused by KBrO₃ in mice models divided into four groups: controls, KBrO₃, KBrO₃ + A. corallinum, and A. corallinum. Our results demonstrated the rich composition of A. corallinum in antioxidant compounds like phenolics, flavonoids, anthocyanins, polysaccharides, chlorophyll and carotenoids. Its antioxidant activity was also confirmed using β-carotene bleaching by linoleic acid assay, reducing sugar test and trolox equivalent antioxidant capacity. The ethanolic extract of A. corallinum also showed good inhibition of the tested bacteria. The coadministration of the red alga associated to the KBrO₃ alleviated hepatotoxicity as monitored by the improvement of hepatic oxidative stress biomarkers and plasma biochemical parameters, when compared to the KBrO₃-treated mice. These results were confirmed by the improvement of histological and molecular changes. Treatment with A. corallinum prevented liver damage induced by KBrO₃, thus protecting the body against free radicals and reducing inflammation and hypercholesterolemia risks.
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