Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc
2012
Qayum, Mughal | Nisar, Muhammad | Shah, Muhammad Raza | Adhikari, Achyut | Kaleem, Waqar Ahmad | Khan, Inamullah | Khan, Nematullah | Gul, Farah | Khan, Ihsan Ali | Zia‐ul‐Haq, M. | Khan, Abad
A study was conducted to identify constituents that might be responsible for analgesic and antiinflammatory conditions. Tasumatrol B, 1,13‐diacetyl‐10‐deacetylbaccatin III (10‐DAD) and 4‐deacetylbaccatin III (4‐DAB) were isolated from the bark extract of Taxus wallichiana Zucc. All the compounds were assessed for analgesic and antiinflammatory activities using an acetic acid‐induced writhing model, a hot‐plate test, a carrageenan‐induced paw oedema model, a cotton‐pellet oedema model and in vitro lipoxygenase inhibitory assay. All the compounds, especially tasumatrol B, revealed significant analgesic activity in comparison to a saline group based on an acetic acid‐induced model. Similarly all of the test compounds, particularly tasumatrol B, showed significant antiinflammatory activity. However, all the compounds failed to exhibit any considerable activity in of the hot‐plate test and the in vitro lipoxygenase inhibitory assay. This study has highlighted the potential of tasumatrol B to be further explored as a new lead compound for the management of pain and inflammation, one that has been discovered by scientific validation of the traditional medicinal use of T. wallichiana Zucc.
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