Predictors and markers of resistance to neurotropic nematode infection in rodent host
2006
Hõrak, Peeter | Tummeleht, Lea | Talvik, Heli
Parasite-mediated selection is currently believed to play an important role in life-history evolution. To assess how simple hematoserological and biochemical condition indices reflect host immunocompetence and infection resistance controlled laboratory experiments are required. We addressed these issues by infecting laboratory rats with the standard dose of embryonated eggs of a neurotropic nematode Toxocara canis. Urine baseline corticosterone concentrations, measured 1 week before infection, predicted the number of nematode larvae later recovered from host brains. Thus, this noninvasive clinical marker appeared useful for assessment of potential infection resistance. Rats who had accumulated high number of larvae in their brains and muscle had large spleens and high peripheral eosinophil counts 17 days postinfection. This finding is consistent with the concept that induction of eosinophilic Th2 type humoral immune response benefits the parasite rather than host. Hence, excessive peripheral eosinophilia and spleen enlargement are not markers of efficient antiparasite response in larval toxocariasis.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por National Agricultural Library