Biomonitoring of ochratoxin A in blood plasma and exposure assessment of adult students in Bangladesh
2014
Ali, Nurshad | Blaszkewicz, Meinolf | Manirujjaman, M. | Perveen, Rasheda | Nahid, Abdullah Al | Mahmood, Shakil | Rahman, Mustafizur | Hosāina, Khāleda | Degen, Gisela H.
SCOPE: Ochratoxin A (OTA), a mycotoxin known for its nephrotoxic, immunotoxic, and carcinogenic effects in animals, deserves attention due to its widespread occurrence as food and feed contaminant. Studies in many countries report the presence of OTA in human blood plasma or serum at variable levels. However, no biomonitoring study has been carried out in so far, and also food analysis data are insufficient to assess OTA exposure. METHODS AND RESULTS: Therefore, 64 blood samples were collected from healthy university students (32 female, 32 male) in Bangladesh for biomarker analysis. OTA and its metabolite ochratoxin alpha were determined in the plasma samples by a validated method using HPLC‐fluorescence analysis. After liquid–liquid extraction, OTA was detected in all plasma samples (100%) at a range of 0.20–6.63 ng/mL and ochratoxin alpha was detected in 95% of the samples at 0.10–0.79 ng/mL. The OTA mean level in plasma of males (0.92 ± 1.09 ng/mL) and females (0.78 ± 1.02) were not significantly different. Statistical analysis of food consumption data for the participants, provided in a food frequency questionnaire, did not reveal a significant association between OTA level in plasma and their intake of typical staple foods (rice, wheat, maize, and lentil). CONCLUSION: The dietary intake of OTA (mean 11.7, max 91.7 ng/kg b.w./wk) calculated on the basis of plasma concentration in Bangladeshi students was lower than the tolerable weekly OTA intake (120 ng/kg b.w./wk) set by EFSA. Nonetheless, further biomonitoring is recommended in cohorts from other parts of the country that may have higher mycotoxin exposure than the present group.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por National Agricultural Library