Efficient solid-phase synthesis of isocytosine derivatives
2009
Novakov, I. A | Orlinson, B. S | Brunilin, R. V | Nawrozkij, M. B | Gordeeva, E. A | Savel‘ev, E. N | Gerasimov, E. N
We have investigated the potential use of a solid-phase synthesis of novel 6-(arylmethyl)-5-methyl-isocytosine derivatives based on the immobilization of the corresponding 2-thiothymine on a Merrifield resin, oxidation of the immobilized form to the sulfone, and aminolysis of the latter under mild conditions.
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