Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes
2011
Ward, Stephen G. | Westwick, J. | Harris, Stephanie
Phosphoinositide 3-kinase (PI3K)-dependent signaling has been placed at the heart of conserved biochemical mechanisms that facilitate cell migration of leukocytes in response to a range of chemoattractant stimuli. This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies.
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