Ultrastructural localization of pemphigus vulgaris antigen on canine keratinocytes in vivo and in vitro
1990
Suter, M.M. | Wilkinson, J.E. | Dougherty, E.P. | Lewis, R.M.
Pemphigus antigens were localized, by use of immunoelectron microscopy, on canine keratinocytes in vivo on esophageal mucosa and in vitro on established cultured keratinocytes. Convalescent sera from a human being with pemphigus vulgaris and a human being with pemphigus foliaceus reacted with the interdesmosomal cytoplasmic keratinocyte membrane of canine esophagus. Cultured canine keratinocytes expressed the pemphigus vulgaris antigen in a similar pattern, but did not carry the pemphigus foliaceus antigen. The differential presence of cell surface antigens and its relation to various forms of the disease are discussed.
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