Low AMY1 Copy Number Is Cross‐Sectionally Associated to an Inflammation‐Related Lipidomics Signature in Overweight and Obese Individuals
2020
Mayneris‐Perxachs, Jordi | Mousa, Aya | Naderpoor, Negar | Fernández‐Real, José‐Manuel | de Courten, Barbora
SCOPE: Reduced amylase 1 (AMY1) copy numbers are associated with obesity, insulin resistance, and inflammation. Although mechanisms linking AMY1 copy number with metabolic disorders are poorly understood, recent findings suggest that lipids play a key role. METHODS AND RESULTS: Plasma lipidomic signatures associated with AMY1 copy number are explored in 57 non‐diabetic overweight/obese subjects aged 18–60. Serum amylase and inflammatory cytokines levels are also measured. AMY1 copy number is strongly associated with the serum amylase concentration. Participants are divided into low‐(≤4) and high‐(>4) AMY1 carriers based on the median. Low‐AMY1 carriers have higher BMI and fat mass. They also have higher levels of dihexosylceramides (R = −0.27, p = 0.044), cholesterol esters (CE) (R = −0.32, p = 0.020), alkylphosphatidylcholines [PC(O)] (R = −0.33, p = 0.014), and sphingomyelins (SM) (R = −0.38, p = 0.005). From 459 lipid species, 28 differ between low‐ and high‐AMY1 carriers. These include CE species with long‐chain PUFA; PC(O) and PC plasmalogens containing arachidonic acid; and PC, mono‐, di‐, and tri‐hexosylceramides, and SM containing saturated fatty acids (mainly C16:0 and C20:0). This lipidomic signature is strongly associated with inflammatory cytokines, which are also negatively associated with the AMY1 copy number. CONCLUSION: A lipidomics signature associated with low AMY1 copy numbers is revealed, which is linked to obesity and chronic low‐grade inflammation.
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