Absence of adverse effects following the gavage administration of methyl propyl trisulfide to Sprague-Dawley rats for 90 days
2018
Bastaki, Maria | Aubanel, Michel | Cachet, Thierry | Demyttenaere, Jan | Diop, Maodo Malick | Harman, Christie L. | Hayashi, Shim-mo | Koetzner, Lee | Krammer, Gerhard | Li, Xiaodong | Llewellyn, Craig | Mendes, Odete | Renskers, Kevin J. | Schnabel, Jürgen | Smith, Benjamin P.C. | Taylor, Sean V.
Methyl propyl trisulfide is a flavoring substance found in foods such as garlic and onions. At the request of the European Food Safety Authority (EFSA) for additional toxicological data on methyl propyl trisulfide, groups of Sprague-Dawley rats (10/sex/group) were gavaged with 0 (corn oil vehicle control), 0.5, 2, or 6 mg methyl propyl trisulfide/kg bw/day in a 90-day GLP-compliant study. No effects on clinical observations, hematology and clinical chemistry parameters, organ weights, or macroscopic and histopathological examinations were found attributable to ingestion of methyl propyl trisulfide. The oral no-observed-adverse-effect level (NOAEL) for rats of both sexes was the highest dose tested of 6 mg/kg bw/day.
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