Taicrypnacids A and B, a Pair of C₃₇ Heterodimeric Diterpenoid Stereoisomers from Taiwania cryptomerioides
2019
Wang, Wenli | Zhu, Dong-Rong | Chen, Chen | Zhu, Tian-Yu | Han, Chao | Liu, Fei-Yan | Li, Ling-Nan | Luo, Jian-Guang | Kong, Ling-Yi
Two uncommon C₃₇ heterodimeric diterpenoids, taicrypnacids A (1) and B (2), and a known labdane-type diterpenoid (3) were isolated from the leaves of Taiwania cryptomerioides. Several techniques, such as comprehensive spectroscopic analysis, chemical conversion, X-ray crystallography, and ECD data, were employed to define the structures. The two new compounds displayed cytotoxicity against human breast cancer (MCF-7), osteosarcoma (U-2 OS), and human colon carcinoma (HCT-116) cell lines, while the methyl ester 1a showed no activity. Compound 1 induced Ca²⁺-ROS pathway-mediated endoplasmic reticulum stress, and excessive stress led to cell death by activating apoptosis and autophagy.
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