The effect of marine n-3 fatty acids in different doses on plasma concentrations of Lp-PLA₂ in healthy adults
2009
Weinkouff Pedersen, Maria | Koenig, Wolfgang | Hagstrup Christensen, Jeppe | Berg Schmidt, Erik
Background Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is an emerging independent risk factor for cardiovascular disease (CVD). Lp-PLA₂ can be modified by lipid lowering drugs, but it is unknown whether diet can reduce plasma levels of Lp-PLA₂. Aim of the study The aim of the trial was to study the effect of marine n-3 polyunsaturated fatty acids (PUFA) on plasma Lp-PLA₂ levels in healthy subjects. Methods Sixty healthy subjects were randomized to a moderate dose (2 g) of n-3 PUFA, a high dose (6.6 g) of n-3 PUFA or olive oil (control) daily for 12 weeks. Plasma Lp-PLA₂ was measured at baseline and after the interventions. Results Plasma Lp-PLA₂ levels were unchanged in all three groups before and after the supplements. Neither did the results differ between groups. There was no correlation between the content of n-3 PUFA in platelets or granulocytes or plasma Lp-PLA₂. Conclusion Marine n-3 PUFA had no effect on plasma levels of Lp-PLA₂ in healthy adults and relatively young people.
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