Some effects of deoxycholate administration on the metabolism of cholesterol in man
1979
Gallo-Torres, Hugo E. | Miller, O. Neal | Hamilton, James G.
In a study of the effects of deoxycholic acid on cholesterol metabolism, 1.5 to 3 g of deoxycholate was administered orally to hypercholesterolemic subjects daily for a period of 4 to 10 weeks, resulting in a marked reduction of serum cholesterol concentration. Studies with 14-C-labeled cholesterol demonstrated that deoxycholate administration decreased absorption of cholesterol from the human intestinal tract. In these subjects, the turnover rate of serum cholesterol was more rapid during therapy with deoxycholate than during control periods. Deoxycholate appeared to influence the intestinal flora as assessed indirectly by analysis of the types of neutral sterols eliminated with the feces. Decreased synthesis of cholesterol during deoxycholate administration was demonstrated in a study with 14-C-mevalonate. It is concluded that deoxycholic acid can have an important role in the regulation of cholesterol metabolism.
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