Two New Antibacterial Chromeno[3,2-c]Pyridine Alkaloids from Whole Plants of Thalictrum scabrifolium
2022
Yin, Geng-Yun | Zhu, Ya-Ning | Wu, Fan | Mi, Qi-Li | Shi, Jian-Quan | Gao, Qian | Zhu, Ling-Chao | Zhou, Tao | Li, Jing | Liu, Xin | Yang, Guang-Yu | Hu, Qiu-Fen | Kong, Wei-Song
Two new chromeno[3,2-c]pyridine alkaloids, 9-acetyl-7-methoxy-3-methyl-10H-chromeno[3,2-c]pyridin- 10-one (1) and 8-acetyl-7-methoxy-3-methyl-10H-chromeno[3,2-c]pyridin-10-one (2), were isolated from the whole plants of Thalictrum scabrifolium. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their antibacterial activity. The results showed that both compounds showed high antibacterial activity against 12 microbial strains isolated from the saliva of smokers.
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