Novel AI-2 quorum sensing inhibitors in Vibrio harveyi identified through structure-based virtual screening
2012
Zhu, Peng | Peng, Hanjing | Ni, Nanting | Wang, Binghe | Li, Minyong
In this letter, a high-throughput virtual screening was accomplished to identify potent inhibitors against AI-2 quorum sensing on the basis of Vibrio harveyi LuxPQ crystal structure. Seven compounds were found to inhibit AI-2 quorum sensing with IC₅₀ values in the micromolar range, and presented low cytotoxicity or no cytotoxicity in V. harveyi.
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