Reduced cyclic AMP response to adrenergic stimulation in brain slices from perinatally undernourished rats
1994
Laino, C.H. | Keller, E.A. | Orsingher, O.A.
Cyclic AMP generation response to adrenergic stimulation was assayed in cortical brain slices from adult rats submitted to a protein deprivation schedule in perinatal age and then recovered on balanced chow. Basal cAMP content was similar in deprived and control rats. Higher concentrations of NA (50 to 100 micromolar) induced a lower cAMP response in deprived animals. Selective alpha adrenergic stimulation (NA + timolol) induces the same cAMP response in both control and deprived rats, but potentiation of the beta response was higher in the latter group. On the other hand, selective beta adrenergic stimulation (NA + phentolamine or Isoproterenol) provoked a lower response in deprived animals. onged desipramine treatment reduced response to beta stimulation in control rats but was unable to modify cAMP response in deprived animals, as compared with saline-treated ones. These results stressed long-lasting effects induced by early undernutrition, characterized in this case by the inability to induce neuronal changes to appropriate stimuli.
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