Undernutrition alters the hypothalamic ganglioside profile of the fetal rat
1995
Trindade, V.M.T. | Scotti, L. | Becker, D. | Perry, M.L.S. | Bernard, E.A.
In order to investigate the effect of protein undernutrition on the gangliosides profile, hypothalami of control and undernourished fetal rats were incubated with [6-3H]glucosamine. Tissues were extracted with chloroform: methanol, and the purified ganglioside fractions were chromatographed on TLC plates. Chromatograms from both control and undernourished rats showed the presence of ganglioside bands that comigrated as G(M1), G(D3), G(D1a), G(D1b), G(T1b), and G(Q1b). When the two chromatograms were compared in terms of radioactive ganglioside distribution, the G(D3) label was found to be higher in the hypothalamus of undernourished rats while the G(D1a) label was higher in the hypothalamus of control rats. Since G(D3) predominates during neuroblast and glioblast proliferation, while G(D1a), is important during synaptogenesis, the present data may reflect a delay in hypothalamic development determined by protein undernutrition.
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