Enzymatic Preparation of Genuine Prosapogenin, 20(S)-Ginsenoside Rh₁, from Ginsenosides Re and Rg₁
2000
KO, Sung-Ryong | Suzuki, Yukio | CHOI, Kang-Ju | KIM, Young-Hoi
It was found that a lactase preparation from Penicillium sp. nearly quantitatively hydrolyzed ginsenosides Re and Rg₁, which are major saponins in roots of Panax ginseng, to a minor saponin, 20(S)-ginsenoside Rh₁ [6-O-β-D-glucopyranosyl-20(S)-protopanaxatriol]. This is the first report on the enzymatic preparation of ginsenoside Rh₁ with a high efficiency. This enzyme also readily hydrolyzed ginsenoside Rg₂ to ginsenoside Rh₁.
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